Cymbalta

Cymbalta is a long acting drug that is mainly used to treat depression, though it can be used to treat pain, GAD and urinary incontinence as well.

Cymbalta is a selective serotonin and norepinephrine reuptake inhibitor (SNRI) which is used to help balance these chemicals in the brain. In addition to assisting patients in managing mental disorders such as depression, Cymbalta can be used to stop pain signals in the brain to help manage conditions such as fibromyalgia. SNRIs can help manage your symptoms, but they cannot be used to help cure these conditions. You may need to adjust your medication throughout the course of your treatment to help ensure that your symptoms are still being treated at peak effectiveness. Do not make changes to your prescription without your doctor's instruction to do so.

Indications and Usage

Cymbalta is the brand name for the drug duloxetine, a drug that is used to treat generalized anxiety disorder (GAD) or depression, and may also be used to treat stress urinary incontinence and pain caused by diabetic neuropathy, fibromyalgia and osteoarthritis. Cymbalta is given as a delayed-release capsule which it is to be taken orally twice a day. You may take this medication with or without food, but you should make a point of taking your doses with a meal if you find that you are suffering from nausea or vomiting. Try to take your prescription around the same time every day and do not split, chew or crush the pill when you take it to ensure that you are getting the proper amount of medication in your system at any given time.

Cymbalta Dosage

Adults treating musculoskeletal pain, diabetic peripheral neuropathic pain or fibromyalgia will be given 60 mg once a day. Those treating major depressive disorder will also be given 60 mg once a day. When treating a generalized anxiety disorder can be given 60-120 mg once a day as necessary.

Those with liver or kidney disease may not be able to use Cymbalta as this drug can make their condition worse. You may also need to avoid Cymbalta if you suffer from blood clotting disorders, seizures, glaucoma, bipolar disorder or suicidal thoughts as Cymbalta may interact with the medications that you might be taking for these conditions. Talk with your doctor about appropriate dosing or if it is safe to take Cymbalta if you suffer from any of these conditions.

There is no sufficient evidence regarding whether or not it is safe to use Cymbalta while pregnant or breastfeeding. Talk with your doctor about whether or not the benefits of this medication outweigh any potential risk. If you are using Cymbalta and become pregnant, talk with your doctor about whether or not you will need to adjust your dosing based on the natural hormonal changes that occur during this time.

Indications

Usual Dosage

Special Dosage

Pain or fibromyalgia

60 mg once a day

Those suffering from hepatic insufficiency may not be able to take Cymbalta.

Major depressive disorder

60 mg once a day

Not intended for those who suffer from hepatic insufficiency.

Generalized Anxiety

60-120 mg per day

Cannot be used by those with hepatic insufficiency.

Cymbalta Side Effects

The most common side effect associated with Cymbalta is nausea which occurs in up to 25 percent of users. Other common side effects of Cymbalta include dry mouth which occurs in up to 15 percent of users, headaches in 14 percent, drowsiness in 12 percent, fatigue in up to 11 percent, dizziness in 10 percent, insomnia in up to 10 percent, constipation in up to 10 percent, diarrhea in up to 10 percent, loss of appetite in 9 percent, sweating in 7 percent and abdominal pain in up to 6 percent of users. These side effects are not serious and usually get better as your body becomes accustomed to the medication. Let your doctor know if your side effects are severe or if they get worse over time.

Less common side effects, occurring in 2-5 percent of users, include coughing, vomiting, sore throat, upper respiratory tract infections, runny nose, anxiety, shakiness, weight loss, decreased sex drive, muscle pain, sexual side effects, muscle spasms, flu, blurred vision, hot flashes, yawning, indigestion, and abnormal dreams. These side effects area also not usually severe, but you should let your doctor know if they occur. These may be a sign that you require an adjustment to your prescription size.

If you begin to experience suicidal thoughts, suicide attempts, anxiety or panic attacks, hostility, aggressiveness, engaging in dangerous activities, restlessness, extreme elation, or any other changes in behavior contact your doctor right away. These could be signs that you are having a negative reaction to Cymbalta that could be dangerous. Extreme changes in behavior that are coupled with shakiness, hallucinations or blood pressure changes could also be a sign of serotonin syndrome, a potentially fatal condition that will require immediate attention.

If you experience agitation, fast heartbeat, hallucinating, fever, nausea, loss of coordination, diarrhea, vomiting, seizures, drowsiness, lightheadedness, fainting, dizziness or unresponsiveness after taking Cymbalta you may be suffering from an overdose. Contact emergency medical services immediately to get assistance.

Types of Side Effects

Symptoms

Common Side Effects

Nausea, dry mouth, headaches, drowsiness, fatigue, dizziness, insomnia, constipation, diarrhea, loss of appetite, sweating and abdominal pain.

Uncommon Side Effects

Vomiting, sore throat, runny nose, decreased sex drive, upper respiratory tract infections, coughing, shakiness, muscle pain, sexual side effects, blurred vision, anxiety, weight loss, hot flashes, yawning, indigestion, muscle spasms, flu and abnormal dreams.

Serious Side Effects

Suicidal thoughts, suicide attempts, anxiety or panic attacks, hostility, aggressiveness, engaging in dangerous activities, restlessness, extreme elation, or any other changes in behavior.

Overdose

Agitation, fast heartbeat, hallucinating, fever, nausea, loss of coordination, diarrhea, vomiting, seizures, drowsiness, lightheadedness, fainting, dizziness or unresponsiveness

Interactions

Medications which are known to interact negatively with Cymbalta include warfarin, cimetidine, diuretics, fluvoxamine, linezolid, lithium, St. John's wort, tramadol, tryptophan, antibiotics such as ciprofloxacin, almotriptan, and other antidepressants. These drugs contain similar ingredients to Cymbalta and can increase the effects of this medication. Talk with your doctor regarding any medications you are currently taking before you start using Cymbalta so that you can avoid such a reaction.

Talk to your doctor before you take any medications that are used to take down swelling, such as aspirin, naproxen, indomethacin and others. Taking these drugs in conjunction with Cymbalta can cause you to bruise or bleed more easily.

Do not drink alcohol when using Cymbalta. This can increase your risk of liver damage which can cause a permanent disorder in the body.

Cymbalta may impact your ability to remain alert, and may impair your thinking. Do not do anything that requires you to be alert such as driving until you know how Cymbalta will affect you.

Recommended:

Diovan

Diovan is used to manage high blood pressure. This medication is often prescribed in addition to other medications to manage your condition.


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